Treponemal IgG and IgM response in experimentally infected chimpanzees.

In recent years our studies of experimental syphilis have centred in the use of the chimpanzee as an animal model for the disease. Chimpanzees have been infected with Treponema pallidum, T. carateum, and T. cuniculi. The characteristics of these infections have been described in part or in whole elsewhere (Brown, Kuhn, Tolliver, and Norins, 1970; Chandler, Kaufmann, and Kuhn, 1972; Kuhn 1970, 1971, 1973; Kuhn, Medina, Cohen, and Vegas, 1970; Kuhn, Varela, Chandler, and Osuna, 1968; Kuhn, Brown, and Falcone, 1968). This paper presents changes observed in serum and cerebrospinal fluid (CSF) obtained sequentially from chimpanzees with and without experimentally induced treponematoses.